# MOHAMMAD ATHAR Source: https://hello.cv/mohammadathar ## About Dr Mohammad Athar is an Associate Professor of genomic medicine at the Department of Medical Genetics and Science and Technology Unit, Umm Al-Qura University, Makkah, Saudi Arabia. Dr Athar obtained his PhD in Bioscience from the Jamia Millia Islamia/INMAS-DRDO, Delhi, India, in 2012. Human Molecular Genetics, Functional Genomics and Molecular Medicine are the major disciplines of his area of research. His research interests focus on inherited disorders (Familial hypercholesterolemia, Polycystic Kidney Disease, Haemophilia, and Thrombophilia) using cutting-edge genetic and genomic technologies such as Next-generation sequencing (NGS). He has over ten years of experience in a clinical research laboratory as a PI, Co-I, and Research Scientist on several national-level research grants. Dr Athar contributed significantly to establishing the genetics spectrum of Familial hypercholesterolemia in Saudi populations, in addition to developing high throughput, cost-effective Next-generation Sequencing (NGS) based methods for the molecular diagnosis of inherited disorders. ## Work ### Associate Professor | Umm al-Qura University ### Assistant Professor | Umm Al-Qura University ### Research Scientist | SMS Medical College and Hospital ## Education ### Jamia Millia Islamia | PhD ### Jamia Hamdard | M.Sc. ## Publications ### Proton next generation DNA sequencing [version 1; peer review journal-article ### Deciphering the Structural and Functional Effects of the R1150W Non-Synonymous Variant in SCN9A Linked to Altered Pain Perception NeuroSci journal-article ### Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019 Nature Communications journal-article ### Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019 Nature Communications journal-article ### Deciphering the Structural and Functional Effects of the R1150W Non-Synonymous Variant in SCN9A Linked to Altered Pain Perception NeuroSci journal-article ### Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023 The Lancet Global Health journal-article ### Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 The Lancet Global Health journal-article ### Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage JAMA Neurology journal-article ### Potentials of artificial intelligence in familial hypercholesterolemia: Advances in screening, diagnosis, and risk stratification for early intervention and treatment International Journal of Cardiology journal-article ### Mortality and disability-adjusted life years in North Africa and Middle East attributed to kidney dysfunction: a systematic analysis for the Global Burden of Disease Study 2019 Clinical Kidney Journal journal-article ### Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study The Lancet Regional Health - Southeast Asia journal-article ### Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study The Lancet Regional Health - Southeast Asia journal-article ### Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 The Lancet journal-article ### Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 The Lancet journal-article ### The burden of neurological conditions in north Africa and the Middle East, 1990–2019: a systematic analysis of the Global Burden of Disease Study 2019 The Lancet Global Health journal-article ### Mortality and disability-adjusted life years in North Africa and Middle East attributed to kidney dysfunction: a systematic analysis for the Global Burden of Disease Study 2019 Clinical Kidney Journal journal-article ### Correlation between platelet metrics and cardiovascular risk in prediabetes with coronary artery disease: A two-year cross-sectional study Journal of King Saud University - Science journal-article ### An insight into impact of nanomaterials toxicity on human health. PeerJ journal-article ### Substantial Changes in Selected Volatile Organic Compounds (VOCs) and Associations with Health Risk Assessments in Industrial Areas during the COVID-19 Pandemic Toxics journal-article ### Corrigendum to “Anti- E. coli immunoglobulin yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load” [Heliyon 9(3) (February 21, 2023) e13876]> (Heliyon (2023) 9(3), (S2405844023010836), (10.1016/j.heliyon.2023.e13876)) Heliyon journal-article ### Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 The Lancet journal-article ### Global Burden of Cardiovascular Diseases and Risks, 1990-2022 Journal of the American College of Cardiology journal-article ### SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact Cellular Signalling journal-article ### SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact Cellular Signalling journal-article ### Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights Life journal-article ### Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights Life journal-article ### Novel LDLR Variant in Familial Hypercholesterolemia: NGS-Based Identification, In Silico Characterization, and Pharmacogenetic Insights Life journal-article ### Protein structural insights into a rare PCSK9 gain-of-function variant (R496W) causing familial hypercholesterolemia in a Saudi family: whole exome sequencing and computational analysis Frontiers in Physiology journal-article ### Protein structural insights into a rare PCSK9 gain-of-function variant (R496W) causing familial hypercholesterolemia in a Saudi family: whole exome sequencing and computational analysis Frontiers in Physiology journal-article ### Role of single nucleotide polymorphism rs2383206 on coronary artery disease risk among Saudi Population: a case-control study European Review for Medical and Pharmacological Sciences journal-article ### Role of single nucleotide polymorphism rs2383206 on coronary artery disease risk among Saudi Population: a case-control study European review for medical and pharmacological sciences journal-article ### Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 The Lancet journal-article ### The burden of metabolic risk factors in North Africa and the Middle East, 1990–2019: findings from the Global Burden of Disease Study eClinicalMedicine journal-article ### The burden of metabolic risk factors in North Africa and the Middle East, 1990–2019: findings from the Global Burden of Disease Study eClinicalMedicine journal-article ### Anti-E. coli Immunoglobulin Yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load Heliyon journal-article ### Anti-E. coli Immunoglobulin Yolk (IgY): Reduction of pathogen receptors and inflammation factors could be caused by decrease in E. coli load Heliyon journal-article ### Substantial Changes in Selected Volatile Organic Compounds (VOCs) and Associations with Health Risk Assessments in Industrial Areas during the COVID-19 Pandemic Toxics journal-article ### Substantial Changes in Selected Volatile Organic Compounds (VOCs) and Associations with Health Risk Assessments in Industrial Areas during the COVID-19 Pandemic Toxics journal-article ### The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 The Lancet journal-article ### Variations in the Yamuna River Water Quality During the COVID-19 Lockdowns Frontiers in Environmental Science journal-article ### Identification of Novel and Known LDLR Variants Triggering Severe Familial Hypercholesterolemia in Saudi Families Current Vascular Pharmacology journal-article ### The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019 The Lancet journal-article ### Identification of Novel and Known LDLR Variants Triggering Severe Familial Hypercholesterolemia in Saudi Families Current Vascular Pharmacology journal-article ### Design and optimization of 18-gene Ion AmpliSeq panel of Next-generation sequencing for gene mutation analysis causing pain insensitivity Journal of Umm Al-Qura University for Medical Sciences journal-article ### Variations in the Yamuna River Water Quality During the COVID-19 Lockdowns Frontiers in Environmental Science journal-article ### Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism Clinica Chimica Acta journal-article ### Compound A Increases Cell Infiltration in Target Organs of Acute Graft-versus-Host Disease (aGVHD) in a Mouse Model Molecules journal-article ### Compound a increases cell infiltration in target organs of acute graft-versus-host disease (Agvhd) in a mouse model Molecules journal-article ### Compound a increases cell infiltration in target organs of acute graft-versus-host disease (Agvhd) in a mouse model Molecules journal-article ### Genetic association of rs10757278 on chromosome 9p21 and coronary artery disease in a saudi population International Journal of General Medicine journal-article ### Genetic association of rs10757278 on chromosome 9p21 and coronary artery disease in a saudi population International Journal of General Medicine journal-article ### Mutation Profiling of Intracranial Myxopapillary Ependymoma by Next Generation DNA Sequencing The Gulf journal of oncology journal-article ### Prevalence of the Factor V Leiden Mutation Arg534Gln in Western Region of Saudi Arabia: Functional Alteration and Association Study With Different Populations Clinical and Applied Thrombosis/Hemostasis journal-article ### Prevalence of the Factor V Leiden Mutation Arg534Gln in Western Region of Saudi Arabia: Functional Alteration and Association Study With Different Populations Clinical and Applied Thrombosis/Hemostasis journal-article ### Prevalence of the Factor V Leiden Mutation Arg534Gln in Western Region of Saudi Arabia: Functional Alteration and Association Study With Different Populations Clinical and Applied Thrombosis/Hemostasis journal-article ### Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population International Journal of General Medicine journal-article ### Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 The Lancet Neurology journal-article ### Global, regional, and national burden of stroke and its risk factors, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019 The Lancet Neurology journal-article ### Mutation Profiling of Intracranial Myxopapillary Ependymoma by Next Generation DNA Sequencing Gulf Journal of Oncology journal-article ### Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism Clinica Chimica Acta journal-article ### Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism Clinica Chimica Acta journal-article ### Targeted next-generation sequencing reveals novel and known variants of thrombophilia associated genes in Saudi patients with venous thromboembolism Clinica Chimica Acta journal-article ### EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma Oncology Letters journal-article ### EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma Oncology Letters journal-article ### EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma Oncology Letters journal-article ### Future appeal of comparative studies on putative binding sites of HIV-1 virus-encoded proteolytic enzyme inhibitor of different Food and Drug Administration-approved compounds HIV AIDS Rev journal-article ### Future appeal of comparative studies on putative binding sites of HIV-1 virus-encoded proteolytic enzyme inhibitor of different Food and Drug Administration-approved compounds HIV and AIDS Review journal-article ### Future appeal of comparative studies on putative binding sites of HIV-1 virus-encoded proteolytic enzyme inhibitor of different Food and Drug Administration-approved compounds HIV and AIDS Review journal-article ### Xanthomas Can Be Misdiagnosed and Mistreated in Homozygous Familial Hypercholesterolemia Patients: A Call for Increased Awareness Among Dermatologists and Health Care Practitioners Global Heart journal-article ### Xanthomas can be misdiagnosed and mistreated in homozygous familial hypercholesterolemia patients: A call for increased awareness among dermatologists and health care practitioners Global Heart journal-article ### Xanthomas can be misdiagnosed and mistreated in homozygous familial hypercholesterolemia patients: A call for increased awareness among dermatologists and health care practitioners Global Heart journal-article ### Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing F1000Research journal-article ### Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing F1000Research journal-article ### Whole exome sequencing reveals multiple mutations in uncommon genes of familial hypercholesterolaemia Journal of Cardiovascular Disease Research journal-article ### Identification of six novel factor VIII gene variants using next generation sequencing and molecular dynamics simulation Acta Biochimica Polonica journal-article ### Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome Non-coding RNA research journal-article ### Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome Non-coding RNA Research journal-article ### Association of functional variants and protein-to-protein physical interactions of human MutY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome Non-coding RNA Research journal-article ### Identification of six novel factor VIII gene variants using next generation sequencing and molecular dynamics simulation Acta Biochimica Polonica journal-article ### Identification of six novel factor VIII gene variants using next generation sequencing and molecular dynamics simulation Acta Biochimica Polonica journal-article ### Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia Non-coding RNA research journal-article ### Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia Non-coding RNA Research journal-article ### Modifying inter-cistronic sequence significantly enhances IRES dependent second gene expression in bicistronic vector: Construction of optimised cassette for gene therapy of familial hypercholesterolemia Non-coding RNA Research journal-article ### Molecular Dynamics Simulation Reveals Exposed Residues in the Ligand-Binding Domain of the Low-Density Lipoprotein Receptor that Interacts with Vesicular Stomatitis Virus-G Envelope Viruses journal-article ### Molecular dynamics simulation reveals exposed residues in the ligand-binding domain of the low-density lipoprotein receptor that interacts with vesicular stomatitis virus-G envelope Viruses journal-article ### Molecular dynamics simulation reveals exposed residues in the ligand-binding domain of the low-density lipoprotein receptor that interacts with vesicular stomatitis virus-G envelope Viruses journal-article ### Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing F1000Research journal-article ### Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing [version 1; peer review: 1 approved with reservations] F1000Research journal-article ### Mutation profiling of anaplastic ependymoma grade III by Ion Proton next generation DNA sequencing [version 1; peer review: 1 approved with reservations] F1000Research journal-article ### Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by Ion Proton Oncology Letters journal-article ### Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by ion proton Oncology Letters journal-article ### Next generation DNA sequencing of atypical choroid plexus papilloma of brain: Identification of novel mutations in a female patient by ion proton Oncology Letters journal-article ### Whole exome sequencing reveals multiple mutations in uncommon genes of familial hypercholesterolaemia J Cardiovasc Dis Res journal-article ### Whole exome sequencing reveals multiple mutations in uncommon genes of familial hypercholesterolaemia Journal of Cardiovascular Disease Research journal-article ### In Silico Approach to Investigate the Structural and Functional Attributes of Familial Hypercholesterolemia Variants Reported in the Saudi Population Journal of Computational Biology journal-article ### In Silico Approach to Investigate the Structural and Functional Attributes of Familial Hypercholesterolemia Variants Reported in the Saudi Population Journal of Computational Biology journal-article ### Next Generation Sequencing on Ion Proton for Mutation Detection in Brain Tumors: Development of Molecular Pathology Assays in the Kingdom of Saudi Arabia The Journal of Molecular Diagnostics journal-article ### Novel combined variants of LDLR and LDLRAP1 genes causing severe familial hypercholesterolemia Atherosclerosis journal-article ### Novel combined variants of LDLR and LDLRAP1 genes causing severe familial hypercholesterolemia Atherosclerosis journal-article ### Novel combined variants of LDLR and LDLRAP1 genes causing severe familial hypercholesterolemia Atherosclerosis journal-article ### Identification of a Novel ATM Missense Mutation by Next Generation Sequencing in Choroid Plexus Papilloma The Journal of Molecular Diagnostics journal-article ### In Silico Approach to Investigate the Structural and Functional Attributes of Familial Hypercholesterolemia Variants Reported in the Saudi Population Journal of Computational Biology journal-article ### Compound heterozygous LDLR variant in severely affected familial hypercholesterolemia patient Acta Biochimica Polonica journal-article ### Compound heterozygous LDLR variant in severely affected familial hypercholesterolemia patient Acta Biochimica Polonica journal-article ### Compound heterozygous LDLR variant in severely affected familial hypercholesterolemia patient. Acta Biochimica Polonica journal-article ### Identification of four novel factor VIII gene mutations and protein structure analysis using molecular dynamic simulation J Genet Syndr Gene Ther journal-article ### Molecular Analysis of Factor VIII and Factor IX Genes in Hemophilia Patients: Identification of Novel Mutations and Molecular Dynamics Studies Journal of clinical medicine research journal-article ### The spectrum of familial hypercholesterolemia (FH) in Saudi Arabia: Prime time for patient FH registry Open Cardiovascular Medicine Journal journal-article ### The Open Cardiovascular Medicine Open Cardiovascular Medicine Journal journal-article ### The spectrum of familial hypercholesterolemia (FH) in Saudi Arabia: prime time for patient FH registry The open cardiovascular medicine journal journal-article ### The spectrum of familial hypercholesterolemia (FH) in Saudi Arabia: Prime time for patient FH registry Open Cardiovascular Medicine Journal journal-article ### 1. Founder mutation identified in the LDLR gene causing familial hypercholesterolemia associated with increased risk of coronary heart disease Journal of the Saudi Heart Association journal-article ### 4. Identification of a novel nonsense variant C. 1332DUP, P.(D445*) in the LDLR gene that causes familial hypercholesterolemia Journal of the Saudi Heart Association journal-article ### Compound heterozygous mutation in the LDLR gene in Saudi patients suffering severe hypercholesterolemia Human Genomics journal-article ### Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) BMC Genomics conference-paper ### Association of functional variants and protein physical interactions of human MUTY homolog linked with familial adenomatous polyposis and colorectal cancer syndrome Human Genomics journal-article ### Functional alterations due to amino acid changes and evolutionary comparative analysis of ARPKD and ADPKD genes Genomics data journal-article ### Functional alterations due to amino acid changes and evolutionary comparative analysis of ARPKD and ADPKD genes Genomics Data journal-article ### Functional alterations due to amino acid changes and evolutionary comparative analysis of ARPKD and ADPKD genes Genomics Data journal-article ### Identification of a recurrent frameshift mutation at the LDLR exon 14 (c. 2027delG, p.(G676Afs* 33)) causing familial hypercholesterolemia in Saudi Arab homozygous children Genomics journal-article ### Identification of a recurrent frameshift mutation at the LDLR exon 14 (c.2027delG, p.(G676Afs*33)) causing familial hypercholesterolemia in Saudi Arab homozygous children Genomics journal-article ### Identification of a recurrent frameshift mutation at the LDLR exon 14 (c.2027delG, p.(G676Afs*33)) causing familial hypercholesterolemia in Saudi Arab homozygous children Genomics journal-article ### Ion torrent next generation sequencing of recessive polycystic kidney disease in Saudi patients Human Genomics journal-article ### Mutation Screening of the Factor VIII Gene in Hemophilia A in Saudi Arabia: Two Novel Mutations and Genotype-Phenotype Correlation Journal of Molecular and Genetic Medicine journal-article ### Next-generation sequencing for molecular diagnosis of autosomal recessive polycystic kidney disease Gene journal-article ### Next-generation sequencing for molecular diagnosis of autosomal recessive polycystic kidney disease Gene journal-article ### Next-generation sequencing for molecular diagnosis of autosomal recessive polycystic kidney disease Gene journal-article ### Molecular genotyping of haemophilia A in Saudi Arabian population: report of novel mutations JOURNAL OF THROMBOSIS AND HAEMOSTASIS conference-paper ### Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease Gene journal-article ### Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease Gene journal-article ### Next generation sequencing to identify novel genetic variants causative of autosomal dominant familial hypercholesterolemia associated with increased risk of coronary heart disease Gene journal-article ### Identification of novel genetic mutations in low-density lipoprotein receptor (LDLR) gene causing familial hypercholesterolemia in Saudi Arab homozygous children JOURNAL OF THROMBOSIS AND HAEMOSTASIS conference-paper ### DNA mismatch repair MSH2 gene-based SNP associated with different populations Molecular Genetics and Genomics journal-article ### DNA mismatch repair MSH2 gene-based SNP associated with different populations Molecular Genetics and Genomics journal-article ### Evidence of Trem2 variant associated with triple risk of alzheimer's disease PLoS ONE journal-article ### Evidence of Trem2 variant associated with triple risk of alzheimer's disease PLoS ONE journal-article ### Evidence of trem2 variant associated with triple risk of Alzheimer’s disease PloS one journal-article ### Identification of a novel nonsense variant c. 1332dup, p.(D445*) in the LDLR gene that causes familial hypercholesterolemia Human genome variation journal-article ### Identification of a novel nonsense variant c.1332dup, p.(D445*) in the LDLR gene that causes familial hypercholesterolemia Human Genome Variation journal-article ### Identification of a novel nonsense variant c.1332dup, p.(D445*) in the LDLR gene that causes familial hypercholesterolemia Human Genome Variation journal-article ### DNA mismatch repair MSH2 gene-based SNP associated with different populations Molecular Genetics and Genomics journal-article ### Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells Molecular and Cellular Biochemistry journal-article ### Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells Molecular and Cellular Biochemistry journal-article ### Hoechst 33342 induced reactive oxygen species and impaired expression of cytochrome c oxidase subunit 1 leading to cell death in irradiated human cancer cells Molecular and cellular biochemistry journal-article ### Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species Free radical research journal-article ### Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species Free Radical Research journal-article ### Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species Free Radical Research journal-article ## Source Read this profile on Hello.cv: https://hello.cv/mohammadathar Create your free profile at https://hello.cv